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High BMI linked to adenoma detection at colonoscopy
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LAS VEGAS — Overweight or obese patients are more likely to have adenomatous polyps detected during colonoscopy than patients with lower BMI, according to data presented at the 2012 of Gastroenterology Annual Scientific Meeting.
Researchers calculated BMI and adenoma and polyp detection rates for 430 patients who underwent colonoscopy between March 2011 and July 2011. Patients were grouped and analyzed according to BMI: less than 25 kg/m2 (45.1% of the cohort), between 25 and 29 kg/m2 (38.4%), between 30 and 34 kg/m2 (10.5%) and more than 35 kg/m2 (6.0%). The mean BMI for the cohort was 26.0.
“We know there are associations between colon cancer and obesity, but before this there hadn’t been an identified increased adenoma [detection] rate; it hadn’t been correlated with colonoscopy yet,” researcher , , in , told Healio.com.
Overall polyp detection rate was 57.4%; adenoma detection rate was 44%. Adenomas were located in the cecum and ascending colon in 35.5% of cases. Univariate analysis indicated associations between polyp detection rate and BMI, age and gender (P=.001). Adenoma detection rate was associated with BMI in the entire colon (P=.003), specifically the right colon (P=.009).
Multivariate analysis adjusting for factors including age, gender, type and quality of bowel preparation, race and comorbidities, indicated an independent association between BMI and adenoma detection in the entire (P=.032) and the right colon (P=.045). A subset analysis of patients with BMI between 30 kg/m2 and 34 kg/m2 indicated an OR of 3.03 (95% CI, 1.33-6.90) for adenoma detection in the right colon compared with patients with BMI less than 25 kg/m2.
“There’s a clear significance for adenoma detection in the right colon, as well as the entire colon, with increasing BMI,” Ma said. “If you’re obese or overweight, there’s an increased risk for adenoma, and this may be an important risk group that we need to stratify further with screening guidelines. Definitely make sure that your [patients with] BMI over 30 are seen for increased-risk screening; make sure they get their colonoscopy on time.”
For more information:
Ma H. P1468: Higher BMI Is Associated with Increased Detection of Adenomatous Polyps During Colonoscopy. Presented at: the 2012 American College of Gastroenterology Annual Scientific Meeting; Oct. 19-24, Las Vegas.