Thyroid News

Top-line results from the OPTIC trial showed that the phase 3 study met its primary endpoint, demonstrating that more patients with active thyroid eye disease assigned teprotumumab experienced a meaningful improvement in proptosis, or protrusion of the eyeball, compared with patients assigned placebo, according to a press release from Horizon Pharma.

Adults with acromegaly may be prone to developing nodular thyroid disease and advanced nodule growth, according to findings published in Pituitary.

Adults with thyroid-stimulating hormone-secreting pituitary adenomas have a greater chance of biochemical remission after undergoing adjuvant treatment compared with neoadjuvant therapies, according to findings published in Pituitary.

PoinT

With an estimated incidence of four cases per million population year, thyroid cancer that does not respond to radioactive iodine therapy is rare. For most of those patients, the prognosis is poor, with a 10-year survival rate of 10% from the time metastatic lesions are detected. Until recently, physicians had little to offer patients in the way of treatment.

Chinese women with a low serum iodine concentration during pregnancy were 2.4 times more likely to develop hypothyroxinemia vs. women with a higher iodine concentration, whereas a high iodine concentration during pregnancy was related to risk for thyrotoxicosis, according to findings published in Clinical Endocrinology.

Adults with thyroid eye disease or Graves’ disease without orbitopathy have greater understanding of thyroid eye disease than the general population, but still exhibit some knowledge gaps, according to findings published in Thyroid.

Thyroid nodules may be associated with lower thyroid-stimulating hormone values and higher free thyroxine levels in iodine-sufficient pregnant women, according to findings published in Thyroid.

Patients with intermediate or high-risk differentiated thyroid cancer may not benefit from thyrotropin suppression with levothyroxine, according to results of a retrospective study published in JAMA Network Open.

Endocrinologists are more likely to prescribe brand-name thyroid hormone drugs vs. general practitioners, despite an overall increase in the dispensing of generic thyroid hormone therapies over 10 years, according to findings published in The Journal of Clinical Endocrinology & Metabolism.