Neuroendocrinology News

Adults with acromegaly have an elevated risk for colon polyps, and those who have a higher level of insulin-like growth factor I at diagnosis appear to have an even greater risk compared with those who have a lower level, despite delayed diagnosis of acromegaly or presence of comorbidities, according to study results from Mexico.

Adults with acromegaly are more likely to have subclinical atherosclerosis and structural and functional damage to the heart compared with healthy adults, according to findings published in Endocrine Practice.

An “aggressive” surgical approach for most neuroendocrine tumors prolonged overall survival and resulted in low morbidity in most patients, according to findings from a retrospective survival analysis published in the Journal of the American College of Surgeons.

177Lu-Dotatate conferred longer PFS and a significantly higher response rate than high-dose octreotide long-acting repeatable in patients with advanced midgut neuroendocrine tumors, according to results of the randomized, controlled, open-label, phase 3 NETTER-1 trial published in The New England Journal of Medicine.

Adults with childhood-onset and young adult-onset hypothalamic pituitary conditions may fail to achieve social milestones compared with adults with a nonfunctioning pituitary adenoma, study data show.

Certain cells in the anterior pituitary can react much more quickly to stress than previously believed, according to researchers in Germany.

In adults with multiple endocrine neoplasia type 1, or MEN1, the timing and extent of surgical intervention for pancreaticoduodenal neuroendocrine tumors must be weighed against the risk for meaningful morbidity, including exocrine and endocrine pancreatic insufficiency and worsening quality of life, according to a retrospective analysis of patient data.

The European Commission’s revised proposal of regulations to define and identify endocrine-disrupting chemicals is based on unnecessarily narrow criteria that will make it difficult to regulate these chemicals, the Endocrine Society said in a statement.

Approximately 22.1% of childhood brain tumor survivors developed at least one endocrine disorder within 5 years after diagnosis, according to a nationwide, multicenter study.

Gonadotropin and adrenocorticotropic hormone deficiencies in adults with nonfunctioning pituitary adenomas are tied to an increased risk for mortality, according to study findings recently published in Clinical Endocrinology.