Neuroendocrinology News

CHICAGO — Neuroendocrine tumors are a heterogeneous group of neoplasms with a complex interaction of pathways, and despite the evolution of several systemic therapies, much remains to be discovered, according to a speaker here.

CHICAGO — Adults with acromegaly have an increased risk for excess morbidity and mortality, especially related to circulatory and malignant diseases, according to a presenter at the Endocrine Society Annual Meeting.

Excess mortality for adults diagnosed with acromegaly has markedly declined in past 3 decades, with researchers also observing an increase in the use of pituitary surgery and a decrease in the prevalence of hypopituitarism as more patients are prescribed pharmacotherapy, according to findings from a nationwide analysis conducted in Sweden.

Patients with aggressive pituitary tumors and carcinomas should be treated by a multidisciplinary team and receive full endocrine laboratory evaluation and histopathologic analyses for tumor classification, according to recommendations included in new a clinical practice guideline released by the European Society of Endocrinology.

Among adults with acromegaly who undergo transsphenoidal adenomectomy, premenopausal women have a worse long-term remission rate and are more likely to have remnant mass and higher serum growth hormone levels compared with postmenopausal women and men, study data show.

Patients with acromegaly that is controlled through medication or in remission continue to have a higher prevalence of diabetes than the general population, according to a retrospective study by researchers in France.

Men with prolactinoma are at higher risk for incident cardiovascular disease compared with women with prolactinoma and healthy men and women, according to findings published in Clinical Endocrinology.

A 63-year-old man was referred to the Massachusetts General Hospital Neuroendocrine & Pituitary Tumor Clinical Center for management of a pituitary macroadenoma.

Adults with craniopharyngioma, whether onset was during childhood or adulthood, have increased risks for developing diabetes, new intracranial tumors, all-cause mortality, cardiovascular disease and cerebrovascular disease, study data show.

Women with childhood-onset combined pituitary hormone deficiencies have successful pregnancies when treated with adequate hormone replacement before ovarian stimulation, according to findings published in the Journal of the Endocrine Society.