Hormone Therapy News

Treatment with recombinant human growth hormone does not increase the risk for nonfunctioning pituitary adenoma or craniopharyngioma among adults with GH deficiency, according to an analysis of retrospective data published in The Journal of Clinical Endocrinology & Metabolism.

A leuprolide acetate suspension to be dosed every 6 months has been approved by the FDA for use in treating children aged at least 2 years with central precocious puberty, according to a press release from Tolmar Pharmaceuticals.

As researchers continue to assess complications of COVID-19, one striking difference has become clear — men who contract the novel coronavirus are more likely to be intubated or die compared with women. Animal model studies of the SARS virus suggest that the age and sex differences in COVID-19 symptom severity may be due to the protective and acute actions of estrogen, and researchers are initiating a trial designed to find out whether a transdermal estrogen patch placed on the skin of COVID-19-positive patients can reduce symptom severity compared with regular care.

Among a large cohort of Canadian women, premature menopause and current use of hormone therapy were associated with self-reported depression, according to results from a study published in Menopause.

Among a large cohort of transgender adults prescribed gender-affirming hormones, higher levels of cross-sex hormones did not increase the odds of hypertension, and hypertension diagnoses were fewer among transgender women who were ever prescribed progestins, according to data published in Transgender Health.

Although ESR1 mutations are rare at the time of primary breast cancer diagnosis, they predict eventual resistance to standard adjuvant hormone therapy, according to study results presented at the virtual American Association for Cancer Research Annual Meeting.

Alan J. Garber, MD, PhD, MACE, a leading expert on diabetes and cardiometabolic disorders and long-time chief medical editor of Endocrine Today, died Thursday, April 9.

The effect of testosterone supplements on bone mineral density and the risk for fracture or falling among men with testosterone deficiency remains inconclusive, according to findings published in BMC Endocrine Disorders.

Among men with HIV, those who used testosterone therapy had elevated risk for significant coronary artery calcium progression compared with those who did not, according to an abstract presented at CROI.

Women in early menopause who received oral estradiol treatment had a reduced progression of lipid deposition in the carotid arterial wall compared with placebo, according to a secondary analysis of the ELITE trial presented at the American Heart Association Epidemiology, Prevention, Lifestyle and Cardiometabolic Health Scientific Sessions.