Bone/Mineral Metabolism News

CHICAGO — A total sperm count of less than 39 million per ejaculate may place men at increased risk for poorer metabolic, cardiovascular and bone health compared with men with higher total sperm counts, according to findings presented here.

CHICAGO — Postmenopausal women with osteoporosis saw increased bone mineral density and reduced fracture risks over 43 months with alendronate follow-up to both abaloparatide therapy and placebo, but improvements were substantially greater with the abaloparatide-alendronate regimen, according to results of a prespecified responder analysis of ACTIVExtend data reported here.

The use of daily supplemental calcium in the U.S. rose steadily from 1999 before peaking in 2007-2008 and then declined each year since, with calcium supplement use highest among older white women, according to an analysis of National Health and Nutrition Examination Survey data.

Adults with type 2 diabetes who lost at least 30% of their maximum body weight had increased risks for fragility fractures and any fracture compared with those who lost less weight, according to findings published in Diabetes Care.

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Women on bisphosphonates for at least 3 years who took a drug holiday for at least 12 months do not appear to have an increased risk for any osteoporosis-related fracture compared with women who persistently used bisphosphonates and those who were not adherent to persistent use, study data show.

Adults with pre-sarcopenia or sarcopenia are no more likely to sustain a fracture than adults with osteoporosis without sarcopenia, according to findings published in the Journal of Bone and Mineral Research.

Among healthy adults, lower levels of circulating insulin-like growth factor I are associated with increased risk for fracture, with the risk more pronounced among men, according to findings from a population-based study published in Clinical Endocrinology.

Postmenopausal women with osteoporosis and 25-hydroxyvitamin D levels less than 30 ng/mL were more likely to experience acute-phase reaction after zoledronic acid infusion compared with those with higher vitamin D levels, according to study results.

Adults with nonalcoholic fatty liver disease and type 2 diabetes had impaired collagen type 1 C-telopeptide suppression in response to an oral glucose tolerance test but not after an IV glucose infusion, study data show.