Bone/Mineral Metabolism News

DESTIN, Fla. —Patients with osteoporosis treated with romosozumab demonstrated substantial gains in bone mineral density and T-score increases within 1 year, with continued progress following transition to denosumab, according to findings presented at the 2018 Congress of Clinical Rheumatology.

The FDA expanded the indication for the monoclonal antibody denosumab to include the treatment of glucocorticoid-induced osteoporosis in men and women at high risk for fracture, according to a press release from Amgen.

In an analysis of several adiposity measures, abdominal fat was the mostly strongly associated with vitamin D concentration in men and women, according to study findings presented at the European Congress of Endocrinology annual meeting.

Young women with Turner syndrome did not incur fractures more frequently than those without the disease; however, fracture location differed between the two groups, according to study results.

BOSTON — A fundamental aging mechanism that drives tissue dysfunction throughout the body may serve as a novel target in the treatment of osteoporosis, suggesting an exciting new pathway for researchers in a field where a “perfect” therapy has remained elusive, according to a speaker at the American Association of Clinical Endocrinologists annual meeting.

Sundeep Khosla, MD, professor of medicine and physiology at the Mayo Clinic College of Medicine, director of the Mayo Clinic Center for Clinical and Translational Science and consultant in the division of endocrinology, diabetes, metabolism and nutrition at Mayo Clinic in Rochester, Minnesota, was awarded the Frontiers in Science Award by the American Association of Clinical Endocrinologists at its annual meeting.

BOSTON — Children with X-linked hypophosphatemia treated with the monoclonal antibody burosumab for 40 weeks saw increased serum concentrations of phosphorous and decreased rickets severity, according to results of two phase 2 studies presented here.

BOSTON — Among adults with obesity, the lumbar spine ratio of bone mineral density to BMI may better predict fracture risk than BMD value alone, particularly when health care providers are unable to calculate trabecular bone score, according to study data presented at the American Association of Clinical Endocrinologists annual meeting.

Approximately 15% of patients with osteoporosis who stop taking bisphosphonates experience bone fractures, according to study results published in Endocrine Practice.

Female U.S. Army recruits who underwent 8 weeks of basic combat training experienced marked changes in bone microarchitecture and key biomarkers of bone metabolism, according to findings from an observational study utilizing high-resolution bone imaging.