Bone/Mineral Metabolism News

Young children with X-linked hypophosphatemia saw significant improvements in rickets and phosphate homeostasis after 63 weeks of biweekly treatment with the monoclonal antibody burosumab, according to findings published in The Lancet Diabetes & Endocrinology.

The Japanese Ministry of Health, Labor and Welfare granted a marketing authorization this week for the monoclonal antibody romosozumab for the treatment of osteoporosis in patients at high risk for fracture, Amgen and UCB Pharma announced in a press release.

Healthy adolescent girls exposed to combined hormonal contraception experienced less bone mineral density accrual at the lumbar spine over 24 months vs. those not exposed to hormonal birth control methods, according to findings from a systematic review and meta-analysis.

Hyponatremia in adults with diabetes is associated with a threefold increased risk for osteoporosis and a sixfold increased risk for fragility fracture, independent of the degree of hyperglycemia, according to findings from a matched case-control study.

Bone mineral density for women with type 1 diabetes was lower at the femoral neck but higher at the lumbar spine compared with BMD for women without diabetes, and those with diabetes experienced more fragility fractures, findings published in the Journal of Diabetes and its Complications show.

Postmenopausal women assigned alendronate therapy are more likely to experience a loss of bone mineral density or an increase in bone turnover markers during a 3-year drug holiday than women assigned zoledronic acid, according to a post hoc analysis of two large trials published in the Journal of Bone and Mineral Research.

Patients who were Holocaust survivors had higher rates of comorbidities and lower rates of mortality compared with an aged-matched control group, according to a study published in JAMA Network Open.

Research published in Annals of Internal Medicine indicated no increased risk for fracture with the use of canagliflozin among patients with diabetes.

Endocrine Today has compiled a list of the top 10 meeting news reports posted in 2018. Healio.com/Endocrinology readers in 2018 were interested in essential oils disrupting endocrine function, semaglutide producing weight loss and the safety of an artificial pancreas.

Endocrine Today has compiled a list of the top 10 FDA approvals and news reports posted in 2018. This year, Healio.com/Endocrinology readers were interested in the Freestyle Libre, rare genital infection associated with SGLT2 inhibitors, BPA in consumer products, testosterone self-injection for hypogonadism and more.