Bone/Mineral Metabolism News

The percentage of midlife women with vitamin D insufficiency and deficiency fell by approximately 50% between 1998 and 2011, in part due to a rise in the use of vitamin D supplements, according to an analysis of data from the Study of Women’s Health Across the Nation.

Only 16% of fractures in women and 15% in men are attributable to low bone mineral density, suggesting that treatment of people based on a diagnosis of osteoporosis is unlikely to reduce a large number of fractures in the overall population, according to an analysis of Australian adults published in The Journal of Clinical Endocrinology & Metabolism.

Children of women who used tenofovir disoproxil fumarate, or TDF, to prevent transmission of hepatitis B to their child did not have lower bone mineral density compared with children who were exposed to placebo, according to findings from a randomized controlled trial published in Clinical Infectious Diseases.

Most postmenopausal women with osteoporosis achieved a T-score above the osteoporosis threshold after receiving 10 years of denosumab therapy, with the incidence of nonvertebral fractures decreasing as a function of bone mineral density, according to findings published in the Journal of Bone and Mineral Research.

The FDA on Tuesday approved the monoclonal antibody romosozumab to treat osteoporosis in postmenopausal women at high risk for fracture, according to a press release from the agency.

Women with type 1 diabetes diagnosed in childhood are more likely to have impaired bone quality in adulthood when compared with similar women diagnosed after age 20 years, further increasing their risk for fracture, according to findings from a cross-sectional study published in Bone.

Adults with diabetes and severe vitamin D deficiency are three times more likely to develop a diabetic foot ulcer than similar patients with sufficient vitamin D levels, according to findings from a meta-analysis published in Nutrition & Diabetes.

In patients with primary hyperparathyroidism, parathyroid hormone level is not associated with incidence of renal stones, low bone mineral density or mortality, suggesting other factors may play a role in predicting adverse outcomes, according to findings from a retrospective cohort study.

Men with eating disorders are at increased risk for low bone mineral density and estimated hip strength compared with healthy controls, with the highest risk observed for men with anorexia nervosa with low body weight and muscle mass, according to findings published in Clinical Endocrinology.

NEW ORLEANS — Minimal-trauma fractures in the lower leg, forearm and upper shoulder are the most prevalent types in adults with a BMI of 50 kg/m2 or more, and comorbidities may be more to blame than elevated BMI, according to findings presented at the Endocrine Society Annual Meeting.