Adrenal News

An assessment of free cortisol after a dexamethasone suppression test could add value to the diagnostic workup of hypercortisolism, which can be plagued by false-positive results, according to data from a cross-sectional study.

An updated guideline for the treatment of Cushing’s disease focuses on new therapeutic options and an algorithm for screening and diagnosis, along with best practices for managing disease recurrence.

Healthy adults with the highest sensitivity to glucocorticoids have a proteomic profile suggesting a greater capability for responding to stressful stimuli compared with those with lowest sensitivity, according to study data.

Elevated levels of stress hormones such as norepinephrine, epinephrine, dopamine and cortisol were associated with increased risk for hypertension, and high levels of cortisol was also linked to CV events, researchers reported.

An international panel reached consensus for pre- and postoperative endocrine testing to manage adults undergoing transsphenoidal surgery, including measurement of prolactin and insulin-like growth factor I levels for all pituitary tumors.

The FDA accepted for review a new drug application for the steroidogenesis inhibitor levoketoconazole for the treatment of endogenous Cushing’s syndrome, according to an industry press release.

The use of topical steroids in infants after cataract surgery can cause changes in the hypothalamic-pituitary-adrenal axis, according to a poster presentation.

An investigational nonsteroidal treatment for classic congenital adrenal hyperplasia improved levels of androstenedione and testosterone for a small cohort of men with the condition, according to data from a phase 2 study.

A large study of mortality in Cushing’s syndrome calculated a threefold higher mortality rate for these patients, with cerebrovascular and atherosclerotic vascular diseases and infection accounting for 50% of deaths, researchers reported.

Only 3% of adults at high risk for primary aldosteronism are screened for the condition, typically only after complications have developed, according to data from a retrospective study presented at the ENDO annual meeting.