Adrenal News

The most common cause of hyponatremia after acute nontraumatic aneurysmal subarachnoid hemorrhage is syndrome of inappropriate antidiuresis, according to data in a recent study. Researchers also reported that acute glucocorticoid insufficiency explains a small but significant number of episodes of hyponatremia.

Prenatal delivery of synthetic glucocorticoids increased the risk of psychiatric disturbance and inattention at age 8 years, according to data in a recently released study.

Poor disease control in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency did not appear to play a role in development of testicular adrenal rest tumors, according to results of a retrospective longitudinal study.

Results from a small survey suggest that endocrinologists were unaware of the safety risks, including adrenal gland problems, associated with the antifungal ketoconazole.

Macronutrients stimulated a postprandial rise in circulating cortisol in lean, healthy men, according to researchers in the United Kingdom.

Multiple courses of prenatal corticosteroid therapy taken by pregnant women did not affect the risk for death or disability in their children, according to data published in JAMA Pediatrics.

Five days of restricted sleep led to increased interleukin-6 levels among young, healthy men and women. Although 2 nights of extended recovery sleep reduced these levels, not all deficits caused by sleep loss improved, according to researchers.

Atterocor Inc. initiated a phase 1 clinical trial today of ATR-101, a drug designed to treat adrenocortical carcinoma, according to a press release. The drug also received orphan drug designation from the FDA and the European Medicines Agency.

Infants demonstrated recovery of the hypothalamic-pituitary-adrenal axis within 6 to 12 weeks of glucocorticoid treatment, and circadian variation in salivary cortisol was also established within 6 weeks, according to data.

Results from a retrospective chart review have characterized the presentation of pheochromocytoma in patients with multiple endocrine neoplasia type 2 as well as its relationship with survival and stage of medullary thyroid cancer in patients with RET 634 mutations.