Adrenal News

The FDA granted orphan drug designation to setmelanotide, a melanocortin-4 receptor (MC4R) agonist, for the treatment of Prader-Willi syndrome, according to a press release from Rhythm.

Small but significant reductions in bone mineral density were found among men with primary adrenal insufficiency receiving prednisolone replacement.

Men with prostate cancer treated with long-term and short-term androgen deprivation therapy are more likely to develop diabetes then men who are not treated with the therapy, according to a meta-analysis in the Journal of Diabetes Investigation.

The appetite-regulating hormone ghrelin reduced the symptoms of early-stage critical limb ischemia in mice, stimulating the development of new capillaries and arterioles and improving blood flow in affected limbs, according to research in Endocrinology.

Prepubertal children treated with the long-acting recombinant human growth hormone somavaratan saw significant improvement in height velocity over 6 months, with no significant differences between assigned dose regimens, according to research in The Journal of Clinical Endocrinology & Metabolism.

A minority of patients display a diversity of pancreatic neuroendocrine tumor hormone secretion at tumor diagnosis or during the course of their disease.

Lower levels of total and free testosterone in men are associated with a higher risk for coronary atherosclerosis, but a lower risk for carotid intima-media thickness, according to research in Clinical Endocrinology.

Blood samples from patients with unilateral hyperaldosteronism revealed higher aldosterone concentrations when compared with patients with bilateral hyperaldosteronism, providing a possible alternative to invasive adrenal venous sampling used to diagnose primary aldosteronism subtypes, according to research in Clinical Endocrinology.

Most adults prescribed glucocorticoid therapy for adrenal insufficiency reported some form of nonadherence to treatment, with many voicing fears of weight gain, osteoporosis and continued risk for adrenal crisis, according to research in Clinical Endocrinology.

In postmenopausal women, high levels of follicle-stimulating hormone may lead to elevated LDL cholesterol through interaction with its receptors in hepatocytes and reductions of LDL receptor levels, thus diminishing the clearance of LDL cholesterol through endocytosis.