Adrenal News

Dutch adults with primary adrenal insufficiency reported abnormal or severe fatigue, reduced physical activity and significantly reduced quality of life vs. healthy controls, according to recent survey results.

A second transsphenoidal surgery for pituitary adenoma can result in remission in approximately half of cases with secreting tumors, with higher success rates in nonsecreting tumors, according to a recent systematic review.

Specific antibodies against gonadotrophs are found in a subset of older men with age-related low testosterone levels; however, whether the antibodies are pathogenic and contributory to age-related declines in testosterone remains unknown, according to data from a proof-of-concept study.

In older men, all-cause and cause-specific mortality are associated with temporal changes in serum testosterone, calculated free testosterone, dihydrotestosterone and estradiol, study findings show.

Healthy men randomly assigned the aromatase-inhibiting drug Arimidex saw reduced insulin resistance at 6 weeks vs. men assigned placebo, according to recent findings.

Prepubertal children with growth hormone deficiency already present with several cardiovascular risk markers, including abnormal lipid profiles, elevated inflammatory and oxidative stress markers, and reduced cardiac mass, according to a recent review.

Discontinuing recombinant human growth hormone therapy in routine clinical practice does not cause significant metabolic changes in older adults, study findings show.

Aromatization to estradiol mediates the tropic effects of testosterone on the prostate, according to study findings published in The Journal of Clinical Endocrinology & Metabolism.

In women undergoing frozen embryo transfer, maternal levels of docosahexaenoic acid appear to increase rapidly before closure of the fetal neural tube, which occurs at 28 days’ gestation, according to recent findings.

In black adults, activation of the renin-angiotensin-aldosterone system may significantly influence the development of insulin resistance and diabetes, according to study findings published in The Journal of Clinical Endocrinology & Metabolism.