Adrenal News

Scalp hair cortisol measurement is an accurate first-line diagnostic test for Cushing’s syndrome in adults and offers several advantages over other first-line diagnostic procedures, according to findings published in the European Journal of Endocrinology.

Height outcome in children with congenital adrenal hyperplasia may be improved with a low hydrocortisone dose and use of mineralocorticoid therapy, according to findings published in Endocrine Practice.

Children with congenital adrenal hyperplasia have an increased risk for overweight or obesity compared with healthy children, but rates of persistent obesity may be lower than previously thought, according to recent data.

Among children with congenital adrenal hyperplasia, those who are younger and those with government insurance may be at increased risk for hospitalization, recent data indicate.

In patients with previous cancers treated with recombinant human growth hormone therapy as children, researchers observed increased risks for both cancer incidence and mortality during long-term follow-up, but no clear cancer-related risk was observed in patients with growth failure without other major disease, according to findings from a population-based European study.

The use of a hair analysis to measure cortisol levels may be an effective initial or supportive test for signaling Cushing’s syndrome, according to recent findings published in Endocrine.

Patients with primary aldosteronism are more likely to sustain a vertebral fracture compared with healthy age- and sex-matched controls, according to recent findings.

Researchers at the Icahn School of Medicine at Mt. Sinai have developed a clinical and genetic profile of steroid 11-hydroxylase deficiency, a rare form of congenital adrenal hyperplasia, which may lead to newborn screening and potential prevention of associated genital ambiguity, according to a press release from the institution.

By adjusting the age and birth weight at which health care providers collected neonatal 17-hydroxyprogesterone samples from newborns, as well as basing neonatal 17-hydroxyprogesterone cutoff levels on the 99.8th percentile, a congenital adrenal hyperplasia screening program for newborns in Brazil improved efficacy, study data showed.

New therapies are needed to better address the comorbidities associated with congenital adrenal hyperplasia, whereas glucocorticoid treatment in pregnant women with the condition remains a matter of debate, according to an overview published in the European Journal of Endocrinology.