Adrenal News

Adults with classic congenital adrenal hyperplasia who received a once-daily, nonsteroidal oral therapy for 12 weeks experienced significant reductions in androgen levels with no serious adverse events, according to findings from a phase 2a study.

The steroidogenesis inhibitor levoketoconazole was effective in reducing and normalizing morning urinary free cortisol concentrations and biomarkers of cardiovascular risk among a large cohort of adults with endogenous Cushing’s syndrome, as well as improving clinical signs of the disease and quality of life measures, according to findings published in The Lancet Diabetes & Endocrinology.

A new predictive model based on Japanese registry data revealed several variables that can predict the normalization of blood pressure after adrenalectomy for primary aldosteronism, including hypertension duration, BMI, number of BP drug prescriptions, diabetes status and sex, according to findings published in the Journal of the Endocrine Society.

Endocrine Today has compiled a list of the top 10 news reports posted so far in of 2019.

Each month Endocrine Today reporters delve deep into a topic of current interest. These longform cover stories provide background and insights from leading researchers and clinicians. All of these features can be found under the opinion tab above and at the links below. Stories published so far in 2019 include emerging alternatives in thyroid cancer treatment, promising developments in beta-cell regeneration, questions about vitamin D’s effectiveness, and more.

An estimated 40% to 50% of childhood cancer survivors will experience an endocrine disorder in their lifetime. The risk varies according to cancer treatment and can persist for decades after diagnosis.

Adults with bilateral pheochromocytomas treated with cortical-sparing adrenalectomy were less likely to need steroid replacement therapy and had a low risk for tumor recurrence over 8 years when compared with similar patients who underwent total bilateral adrenalectomy, according to a retrospective database analysis published in JAMA Network Open.

The concentration of the stress hormone cortisol in the hair during adolescence was associated with depressive symptoms, researchers reported in Psychoneuroendocrinology.

Each month in its cover story, Endocrine Today offers comprehensive reporting on issues of interest to practicing endocrinologists, diabetes educators and other clinicians.

Unilateral adrenalectomy to treat primary aldosteronism can lead to both transient and persistent adrenal insufficiency, and clinicians should perform postoperative adrenocorticotropic hormone stimulation testing to avoid potential adrenal crisis in patients, according to an analysis of registry data.