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August 14, 2023
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VIDEO: Consider drug holiday, switch from bisphosphonate for osteoporosis therapy

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SANTA FE, N.M. — In this video exclusive, Michael R. McClung, MD, discusses strategies for drug holidays and transitions between osteoporosis therapies.

McClung is the founding director of the Oregon Osteoporosis Center in Portland.

Use of bisphosphonates has no incremental benefit after 5 years of therapy, McClung said, and at that time, prescribers should consider a drug holiday or a switch to therapy with denosumab (Prolia, Amgen) or an osteoanabolic agent.

McClung describes special concerns when discontinuing denosumab and reviews arguments for using an osteoanabolic agent as initial therapy.