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Prolactinoma increases CVD risk in men
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Men with prolactinoma are at higher risk for incident cardiovascular disease compared with women with prolactinoma and healthy men and women, according to findings published in Clinical Endocrinology.
Niki Karavitaki , MSc, PhD, FRCP, of the Institute of Metabolism and Systems Research at the University of Birmingham and Centre for Endocrinology, Diabetes and Metabolism at Birmingham Health Partners in the United Kingdom, and colleagues evaluated data from The Health Improvement Network (THIN) database on 2,233 adults with prolactinoma (1,822 women) and 10,355 matched controls (8,557 women) to determine whether the risk for incident CVD is increased in patients with prolactinoma. Mean age of women was 37.1 years and mean age of men was 47.3 years. Participants were observed for 6 years.
The composite CVD outcome was any incident CVD, including myocardial infarction, angina pectoris, stroke, transient ischemic attack or heart failure.
The composite CVD outcome was observed in 54 participants with prolactinoma and 190 controls during the 6-year period. The incidence rate was higher in control women (2 per 1,000 person-years) compared with women with prolactinoma (1.8 per 1,000); however, the incidence rate was higher in men with prolactinoma (14.8 per 1,000) compared with control men (8.7 per 1,000).
After adjustment for age, sex, deprivation quintiles, BMI groups, hypertension, smoking, lipid-lowering medications and diabetes, the adjusted incidence rate ratio was 0.99 in women with prolactinoma compared with control women and 1.94 in men with prolactinoma compared with control men.
“In a population-based, retrospective, open-cohort study, we have shown that men with prolactinoma have increased incident CVD,” Karavitaki told Endocrine Today. “Active management of all risk factors of CVD is required for these patients.” – by Amber Cox
For more information:
Niki Karavitaki , MSc, PhD, FRCP, can be reached at Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, IBR Tower, Level 2, Birmingham, B15 2TT, U.K.
Disclosures: The authors report no relevant financial disclosures.
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