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Vitamin D in adipose tissue normalizes after supplementation cessation
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In adults assigned 5 years of vitamin D supplementation, levels of the vitamin found in the adipose tissue 12 months after the end of supplementation had decreased to levels similar to those of adults who did not use supplementation, according to study findings published in The Journal of Clinical Endocrinology & Metabolism.
Ieva Martinaityte, of the division of internal medicine at University Hospital of North Norway, and colleagues evaluated data from adults randomly assigned 20,000 IU of vitamin D per week (n = 42) or placebo (n = 34) for 5 years to assess changes in serum 25-hydroxyvitamin D and adipose tissue vitamin D levels after stopping vitamin D supplementation. Follow-up was 12 months, and blood samples were drawn at baseline and after 1, 3, 6, 9 and 12 months.
At baseline, mean serum 25-(OH)D levels were 59.9 nmol/L in the vitamin D group and 61.1 nmol/L in the placebo group. During the 12-month follow-up, serum 25-(OH)D levels were significantly higher in the vitamin D group compared with the placebo group.
Over time, serum 25-(OH)D had a linear negative trend in the vitamin D group.
Compared with the placebo group at baseline, the vitamin D group had significantly more vitamin D and 25-(OH)D stored in adipose tissue. Over the 12 months of follow-up, mean vitamin D level in fat tissue among the vitamin D group decreased by 52% and by the end of the study was similar to the level found in the placebo group. In the vitamin D group, significant positive correlations were observed between baseline serum 25-(OH)D, fat 25-(OH)D and fat vitamin D levels (P < .01).
“This proves that long-term intake of vitamin D within the physiological range leads to storage in adipose tissue, and probably also other tissues of possible clinical importance,” the researchers wrote. “To our knowledge, these results have not been demonstrated before.” – by Amber Cox
Disclosures: The researchers report no relevant financial disclosures.
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