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Reduced cardiac function seen in children with obesity, prediabetes
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Tissue Doppler imaging can reveal subclinical evidence of cardiac function deterioration in children and adolescents with obesity and prediabetes, according to study findings, and those with obesity should be monitored for cardiovascular risks in early stages of prediabetes.
Beray Selver Eklioğlu, MD, of the department of pediatrics, division of pediatric endocrinology and diabetes at Necmettin Erbakan University in Turkey, and colleagues used traditional echocardiography parameters and tissue Doppler imaging to evaluate 198 children and adolescents aged 6 to 18 years with obesity to determine their CV and cardiac dysfunction risk. Eighty-one participants had prediabetes as defined by American Diabetes Association criteria.
No difference was observed in carotid intima-media thickness between the groups with and without prediabetes. Left ventricular mass index was greater in the prediabetes group (43.98) compared with the group without prediabetes (40.63; P = .036). Triglycerides (P = .043), systolic blood pressure (P = .039), waist circumference (P = .025) and standard deviation score for body weight (P = .009) were all positively associated with left ventricular mass index; left ventricular mass index and HDL cholesterol were negatively associated (P = .038). Tissue Doppler imaging indicated greater left ventricular E/e’ ratio (P = .043) and left ventricular myocardial velocity (P = .035) in participants with prediabetes.
Left ventricular myocardial velocity was linked to fasting glucose (P = .046), and left ventricular E/e’ ratio was linked to systolic BP (P = .035) in participants with prediabetes.
“Our results indicate that obese prediabetic children are characterized by a higher frequency of increased [left ventricular mass index] and impaired ventricular function,” the researchers wrote. “With this study, we also want to emphasize the importance of glucose and [BP] monitoring in the follow-up of obese children and to state that the assessment of Doppler imaging might be useful in detecting subclinical impairment of cardiac function in prediabetic obese patients at a pediatric age.” – by Amber Cox
Disclosure: The researchers report no relevant financial disclosures.
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