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Glycated albumin, HbA1c levels linked in impaired glucose tolerance
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In Chinese adults with impaired glucose tolerance and undiagnosed diabetes, glycated albumin increases as HbA1c increases, according to a recent analysis.
In a hospital-based, cross-sectional study conducted at 11 centers in China, researchers also found that the ratio of glycated albumin to HbA1c was related to postprandial glucose level and BMI.
“The [glycated albumin]/HbA1c ratio significantly increased with the presence of glucose intolerance in these Chinese study participants,” Yifei Mo, MD, of the department of endocrinology and metabolism at Shanghai Jiao Tong University, and colleagues wrote. “Increased glucose at 30 minutes and decreased BMI were risk factors for an elevated [glycated albumin]/HbA1c ratio.”
Researchers analyzed data from 953 adults without known diabetes (501 men; mean age, 54 years; mean BMI, 24.8 kg/m²). Within the cohort, mean HbA1c was 6.6%; mean glycated albumin was 18.55%. Researchers identified participants as having normal glucose tolerance (n = 194), IGT (n = 303) or newly diagnosed type 2 diabetes (n = 456) via an oral glucose tolerance test, and they recorded glycated albumin, HbA1c and the ratio of glycated albumin to HbA1c.
Researchers found that glycated albumin positively correlated with HbA1c (r = .824; P < .001) after adjusting for age, sex and BMI. In linear regression analysis, a 1% increase in mean HbA1c corresponded to a 2.84% increase in mean glycated albumin.
In all participants, the ratio of glycated albumin to HbA1c correlated with BMI, glucose levels and insulin at 30 minutes during the OGTT, homeostatic model assessment of beta-cell function, delta I30 and delta G30 (P < .05 for all). In a multivariate model including age, sex, BMI and glucose levels during OGTT, an elevated ratio of glycated albumin to HbA1c was associated with elevated glucose at 30 minutes (standardized beta = 0.221; P < .001) and decreased BMI (standardized beta = –0.114; P = .008). – by Regina Schaffer
Disclosure: The researchers report no relevant financial disclosures.
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