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Type 1 diabetes development not linked with serum 25-(OH)D concentrations
Marked changes in serum 25-hydroxyvitamin D concentrations are not associated with the development of type 1 diabetes, according to recent findings.
Further, no apparent differences in the circulating 25-(OH)D concentration were found between children who developed type 1 diabetes and those who did not, according to the researchers.
Marjaana Mä kinen , MSc, of the University of Turku and Turku University Hospital in Finland, and colleagues evaluated data from the Type 1 Diabetes Prediction and Prevention Study on 252 children measured for 25-(OH)D concentration from age 3 months and older using an enzyme immunoassay. Overall, 3,702 prospective serum samples were collected; 126 children were diagnosed with type 1 diabetes and matched with 126 controls by the end of 2012.
No statistically significant differences were found between cases and controls for 25-(OH)D concentrations at different age points as well as median concentration of collected samples (P = .56). Age at seroconversion for autoantibodies (P = .79) and age of disease onset (P = .13) was not associated with 25-(OH)D concentrations.
“Vitamin D intake has been linked to the development of [type 1 diabetes] for quite some time and lower serum 25-(OH)D concentrations have been reported in [type 1 diabetes] patients than in controls all around the world,” the researchers wrote. “It is possible that the reported differences in 25-(OH)D concentrations appear after the diagnosis, since the disease may affect vitamin D metabolism, and there are [type 1 diabetes]-associated complications that result in loss of the vitamin D-binding protein via excretion into urine.” – by Amber Cox
Disclosure: The researchers report no relevant financial disclosures.