Therapeutics News

KOLOA, Hawaii — At Hawaiian Eye 2020, Ashley Brissette, MD, MSc, discusses a case in which a patient presented with chronic allergic conjunctivitis that was not responding to traditional treatments. She found that the patient was on dupilumab for eczema, and the conjunctivitis was a side effect from the drug. She recommends an aggressive treatment regimen to treat the conjunctivitis.

The use of doxycycline to treat patients with idiopathic granulomatous mastitis showed promise as a first-line therapy, according to a descriptive case series published in JAMA Dermatology.

MAUI, HAWAII — Dermatologists who visit the website for Dupixent may be inclined to believe the monoclonal antibody only treats atopic dermatitis, asthma and chronic rhinosinusitis. Similarly, a glance at Stelara’s website may prompt readers to think it only treats Crohn’s disease and ulcerative colitis.

Both ixekizumab and brodalumab were associated with better clinical benefit than other biologic therapies over 12 weeks or 16 weeks of treatment for psoriasis, according to a meta-analysis.

No association was found between exposure to podophyllotoxin during pregnancy and adverse fetal outcomes, according to a registry-based cohort study conducted in Denmark.

Oral propranolol yielded no serious adverse events and few nonserious events in a cohort of infants with PHACE syndrome, according to a study.

The investigational IL-17A and IL-17F inhibitor bimekizumab was superior to adalimumab in achieving a 90% improvement in Psoriasis Area and Severity Index score after 16 weeks, according to a press release from UCB.

Upadacitinib reduced all clinical disease measures including itch-related outcomes at 16 weeks in patients with moderate to severe atopic dermatitis, according to phase 2b study results published in Journal of Allergy and Clinical Immunology.

Common medications to treat acne and other inflammatory dermatoses strongly associated with drug-induced intracranial hypertension include vitamin A derivatives, tetracycline-class antibiotics, recombinant growth hormone and lithium, according to a literature review to help guide dermatologists in a diagnostic and drug-causality algorithm.

Among a large cohort of patients with psoriasis, researchers found around 20% had an immune-mediated inflammatory disease develop before psoriasis onset and 14% had one develop after psoriasis onset, according to a study using data from the Danish National Patient Registry.