Millennials experience higher efficacy, satisfaction with Botox vs. nonmillennials
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Key takeaways:
- More than 90% of nonmillennials responded to treatment vs. 100% of millennials.
- More than 98% of millennials reported satisfaction at days 7, 14 and 30 post-treatment vs. more than 85% of nonmillennials.
Published results showed that millennials saw heightened efficacy with prabotulinumtoxinA in the treatment of moderate to severe glabellar lines.
Millennials, defined as those born between 1982 and 2000, love self-care and consider aesthetic procedures to be not only acceptable, but a normal part of life, according to study author Rui Avelar, MD, the head of research and development and chief medical officer at Evolus.
“Recent evidence indicates that aesthetic treatments, particularly those that are minimally invasive and can be used preventively for aging, are increasingly popular among this cohort,” Avelar wrote. “Globally, neurotoxin injections are the top minimally invasive aesthetic procedure performed.”
Since neurotoxin injections, specifically the 2019 FDA-approved Botox type called prabotulinumtoxinA, are so popular among millennials, Avelar set out to discover why.
A post hoc analysis examined three phase 3 studies where a total of 737 adults, 65 of which were millennials and 668 of which were older nonmillennials, were treated with 20 units of prabotulinumtoxinA for glabellar lines.
Results showed that while the aesthetic outcomes and subject satisfaction of prabotulinumtoxinA treatment were high in nonmillennials, they were even higher in millennials. After evaluating treatment outcomes 7, 14 and 30 days post-treatment, more than 90% of nonmillennials responded to treatment vs. 100% of millennials. This included statistical superiority at day 7 (P = .038) and day 90 (P = .005).
Patient satisfaction was also higher among millennials compared with nonmillennials at all time points, including showing statistical superiority at day 14 (P = .026) and day 30 (P = .01 “The results of this pooled analysis of patients with moderate to severe glabellar lines treated with prabotulinumtoxinA suggest a greater effectiveness in the millennial population compared with older nonmillennials,” Avelar wrote. “It has been observed that the response to [botulinum toxins] may decrease with age.”
Additionally, Avelar hypothesized that the greater efficacy and satisfaction seen in millennials may reflect botulinum toxin’s effects on mood.
“An unintended benefit of aesthetic [botulinum toxin] therapy might be that it makes people happier,” Avelar wrote. “Given that millennials’ objective is to prevent or reverse the aging process, repeat [botulinum toxin] therapy may help meet this objective.”
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