Calcium hydroxylapatite filler shows good results as décolleté wrinkle treatment in women
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Key takeaways:
- At 16 weeks, 73.5% of patients experienced a 1-point or greater improvement in décolleté wrinkle score.
- At least one treatment-emergent adverse event was reported in 53% of patients.
Calcium hydroxylapatite dermal filler may be an option to improve décolleté wrinkles in women, according to a study.
“Calcium hydroxylapatite (CaHA) is a dermal filler indicated for aesthetic procedures, including deep dermal and subdermal soft-tissue augmentation of the facial area and restoration and correction of facial volume loss,” Tatjana Pavicic, MD, in private practice for dermatology and aesthetics in Munich, and colleagues wrote. “Moreover, as a biostimulator, diluted CaHA has been shown to improve skin texture and induce remodeling of the extracellular matrix after subdermal injection, resulting in skin tightening and increased skin thickness.”
In this prospective, evaluator-blinded study, the researchers evaluated the effectiveness and safety of diluted CaHA (Radiesse, Merz Aesthetics) injection to improve décolleté wrinkles in women.
One hundred seventeen women (mean age, 53 years) were randomly assigned to receive either three CaHA injections 8 weeks apart or two CaHA injections 16 weeks apart. Ultimately, 43 patients received three injections and 59 received two injections, while 15 received only one injection.
According to the Merz Aesthetic Scale Décolleté Wrinkles – At Rest scores at baseline, 70.1% of patients scored 2 for moderate décolleté wrinkles and 29.9% scored 3 for severe. At 16 weeks after the last treatment, 73.5% (95% CI, 62.8-82.5) of patients experienced a 1-point or greater improvement in décolleté wrinkle score.
Of those with a moderate baseline score, 73.3% (95% CI, 61-82.9) responded to treatment, while the responder rate in those with a severe baseline score was 89.3% (95% CI, 72.8-96.3).
CaHA had a favorable safety profile in the study with no treatment-related serious adverse events. At least one treatment-emergent adverse event was reported in 53% of patients, serious treatment-emergent adverse events were reported in 7.7%, and one serious treatment-emergent adverse event resulted in study discontinuation.
“Importantly, all events were unrelated to treatment,” the authors wrote. “These study findings demonstrate that diluted CaHA is a safe and effective treatment for décolleté wrinkles in females.”
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