Topical brightener, antioxidant combination improves cases of hyperpigmentation
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A topical brightener and antioxidant combination was well tolerated and improved the appearance of hyperpigmentation and overall quality of skin color among individuals with skin of color, according to a study.
“Hyperpigmentation encompasses a spectrum of conditions caused by several different biological or environmental factors, which ultimately present as aberrant deposition of melanin,” Seemal R. Desai, MD, of the University of Texas Southwestern Medical Center, and colleagues wrote. “The multifactorial nature of pigmentary disorders and differences in melanin biology makes these conditions especially challenging to treat.”
The researchers examined the combination of LYT2, a comprehensive HQ-free, retinol-free cosmetic topical brightener that has previously been shown to improve hyperpigmentation in skin of a variety of different ethnicities and phototypes, and LVS, a dual serum system that provides broad antioxidant protection and supports skin repair.
“Because extrinsic stress and damage can contribute to dyschromia, combining the skin-lightening agent LYT2 with the antioxidant support of LVS could be a rational approach to improve overall skin appearance,” the researchers wrote.
Desai and colleagues enrolled one man and 12 women aged 34 to 54 years in their study. The study population was made up of 23% Asian individuals, 38.5% African American individuals and 38.5% Hispanic individuals.
All patients had previously tried and failed therapy with HQ or other lightening agents. Ten individuals completed the study and the three dropouts were due to withdrawal of consent.
After 12 weeks, treatment with LYT2 and LVS resulted in significant improvements in all efficacy assessments compared with baseline, including overall hyperpigmentation (–23%; P .01), along with skin tone evenness (33%; P .01) and radiance (51%; P .01).
At both 8 and 12 weeks, all patients agreed or strongly agreed regarding improved skin tone evenness and more radiant complexion.
“Facial hyperpigmentation disorders are psychologically debilitating and very common, especially in skin of color individuals,” Desai and colleagues wrote. “Multitargeted or combinatorial approaches are needed to address the range of underlying causes, which must be formally evaluated in darker-skinned individuals due to their unique skin biology.”
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