Capryloyl glycine cream reduces hair growth in female patients compared with placebo
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Capryloyl glycine cream was effective in the treatment of hypertrichosis in female patients compared with placebo, according to findings presented at the American Academy of Dermatology virtual meeting.
“Unwanted body hair is an important cosmetic problem for our patients ... affecting between 5% and 10% of women,” Enzo Berardesca, MD, research professor, University of Miami, said. “The purpose of this study is to evaluate the efficacy of a new molecule that focuses on decreasing the hair growth. It is used in order to reduce the growth of bacteria and in topical use can reduce excessive secretion of sebum.”
In a double-blind placebo-controlled study, 69 patients applied capryloyl glycine 4% topical cream on both forearms twice a day for 120 days. TrichoScan software at 20-fold magnification was used to quantify the growth of hair. Data were analyzed using ANOVA for repeated measures to evaluate changes at three separate study timepoints.
At the study conclusion, patients experienced a significant reduction in total density (P < .001), vellus density (P .02), terminal density (P .001) and median hair length (P .004). A comparison between the active and control groups showed no significant differences until the final follow-up at week 120 (P .001).
“Capryloyl glycine 4% cream is effective. You will see many key parameters related to growth after a few weeks. ... There is very good tolerability and very good compliance from the patients,” Berardesca said. “This treatment can be a safe alternative to a traditional method or can be combined with the traditional method that is systemic therapy.”
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Berardesca E, et al. Assessment of the skin acceptability and efficacy of a cosmetic product in the treatment of hypertrichosis in female patients. Presented at: AAD VMX; June 12-14, 2020 (virtual meeting).
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