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Top news in derm research: Regional dermatoses and dupilumab use
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Researchers from Stanford University discovered new regional dermatoses mainly on the face in a cohort of adults with atopic dermatitis taking dupilumab, in the most popular Healio Dermatology research news from the past week.
Additionally, Victoria Shanmugam, MD, of the division of rheumatology at George Washington University School of Medicine and Health Sciences, and colleagues found that biological pathways are disrupted among patients with hidradenitis suppurativa.
New regional dermatoses reported in some patients taking dupilumab
The 17 patients (23%) who developed new regional dermatoses were more likely to report childhood atopic dermatitis and have autoimmune disease. Fourteen of the patients had facial involvement, and four patients had a history of allergic contact dermatitis confirmed by patch test. Read more.
Alterations in pathway activation found in hidradenitis suppurativa
“This highlights the importance of the immune system in [hidradenitis suppurativa] and identifies deficient or suppressed antimicrobial peptide levels as a possible biomarker in [hidradenitis suppurativa],” Shanmugam told Healio Dermatology. Read more.
Cyclosporin ‘moderately effective’ at inducing remission of alopecia areata
Adults with moderate to severe alopecia areata treated with cyclosporin had a greater reduction in Severity of Alopecia Tool score over time when compared with a placebo group, according to a study. Read more.
Both ivermectin, permethrin yield high clearance rates in scabies
In scabies treatment, oral ivermectin at 200 µg/kg may be associated with slightly lower rates of complete clearance after 1 week compared with 5% permethrin cream, but researchers found little or no difference in complete clearance by weeks 2 and 4. Read more.