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Cutaneous malignancies may be rare complication of hidradenitis suppurativa
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Women with chronic hidradenitis suppurativa experienced rare complications of cutaneous squamous cell carcinoma of the vulvar, perianal and perineal regions, according to study results recently published in Dermatologic Surgery.
Researchers conducted a systematic review and meta-analysis using the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines. A search algorithm was used in PubMed through June 15, 2015.
The algorithm identified and screened 96 articles. Thirteen articles were eligible for the study, including seven studies of nine patients with vulvar carcinoma (mean age, 53.5 years) and six reports of patients perineal/perianal carcinomas (mean age, 49.7 years) in patients with hidradenitis suppurativa (HS).
Almost all the patients in the studies had an advanced form of HS. All malignances were squamous cell carcinomas, except for one case of mucinous adenocarcinoma.
The majority of the cases were advanced carcinomas, with only occasional early-stage carcinomas in the studied population.
“The optimal modifications in the treatment scheme of vulvar, perianal and perineal cancer in patients with HS have not been established; detailed reporting of recurrence and survival-related aspects is advised,” the researchers wrote.
“Cutaneous squamous cell carcinoma of the vulvar, perianal and perineal regions is a rare but serious complication of chronic HS,” the researchers concluded. “Difficulties in recognition may lead to delay in prognosis.” – by Bruce Thiel
Disclosure: The researchers report no relevant financial disclosures.
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