Autologous fat grafting, Xeljanz studies top dermatology reads for week

A literature review finding that autologous fat grafting achieved cosmetic breast augmentation with satisfactory levels of volume retention in some studies was among the most-read articles of the past week on Healio.com/Dermatology.

Other widely read articles included study findings that incidence of major adverse cardiovascular events did not increase with Xeljanz treatment for psoriasis:

Autologous fat grafting achieves volume, patient satisfaction in cosmetic breast augmentation

Autologous fat grafting achieved cosmetic breast augmentation with satisfactory levels of volume retention and satisfaction rates in some studies, according to a literature review recently published in the Aesthetic Surgery Journal.

“Autologous fat grafting is increasingly used in cosmetic surgery,” the researchers wrote. “However, its efficacy and safety are still ambiguous.” Read more

Xeljanz for psoriasis not associated with major adverse cardiovascular events

While there was a small increase in some cholesterol and lipid levels, incidence of major adverse cardiovascular events did not increase with Xeljanz treatment for psoriasis, according to recently published study results.

Researchers measured the effect of Xeljanz (tofacitinib, Pfizer) on cardiovascular risk factors and major adverse cardiovascular events (MACE) in patients with moderate-to-severe plaque psoriasis enrolled in one phase 2 dose-ranging trial and four phase 3 studies. Read more

No significant difference found between Otezla, methotrexate in treating psoriasis

There were no statistically significant differences found in efficacy between Otezla and methotrexate for moderate-to-severe psoriasis, according to recently published study results.

April W. Armstrong, MD, MPH, of the Keck School of Medicine at University of Southern California, Los Angeles, and colleagues conducted a literature review to identify trials that included patients with moderate-to-severe plaque psoriasis who reported 75% improvement in Psoriasis Area and Severity Index score (PASI 75) from baseline to week 16. Read more

Incidence of peristomal pyoderma gangrenosum linked to pre-existing inflammatory bowel disease

Patients with inflammatory bowel disease were at a greater risk for peristomal pyoderma gangrenosum, a subtype of pyoderma gangrenosum, according to study results.

“[Peristomal pyoderma gangrenosum (PPG)] is a diagnosis of exclusion and is often misdiagnosed as suture abscess, contact dermatitis, irritation from stoma leakage, infection, or extension of underlying [Crohn’s disease],” Naiara S. Barbosa, MD, from the department of dermatology at the Mayo Clinic and colleagues wrote. Read more

Recurrent herpes zoster associated with milder symptoms vs. primary herpes zoster

Patients with recurrent herpes zoster exhibited milder clinical symptoms than patients with primary herpes zoster, most likely due to stronger varicella-zoster virus–specific cell-mediated immunity among patients with recurrence, according to study results.

“After infection occurs, [varicella-zoster virus] remains latent in the sensory nerve ganglia throughout the lifetime of the host, with reactivation caused by impairment of immunity, aging, or stress resulting in herpes zoster (HZ),” Yuki Nakamura, MD, of the dermatology department of Nara Medical University School of Medicine, Nara, Japan, and colleagues wrote. Read more