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Family history of CVD predicts first-time MACE risk in young adults with psoriasis
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Young adults with mild or severe psoriasis and a family history of cardiovascular disease had an increased risk for first-time major adverse cardiovascular events compared with those without a family history of cardiovascular disease, according to recently published study results.
Researchers used administrative registers to identify 2,722,375 Danish citizens aged 18 years or older from Jan. 1, 1997, to Dec. 31, 2011. There were 25,774 patients with mild psoriasis and 4,504 patients with severe psoriasis identified from the cohort during a maximum follow-up of 15 years.
The patients had a mean baseline age of 26.6 years. Among patients with mild psoriasis, 62.4% of had a family history (first-degree, parent or sibling) of cardiovascular disease (CVD) as did 66.8% of patients with severe psoriasis.
Incidence rates per 10,000 person-years of incident major adverse cardiovascular events (MACE) in individuals without a family history of CVD were 1.3 the reference population, 1.85 for patients with mild psoriasis, and approximately 6 for patients with severe psoriasis. Incidence rates per 10,000 person-years of MACE for those with a family history of CVD were 17.88 for the reference population, 35.68 for those with mild psoriasis and 45.27 for those with severe psoriasis.
The adjusted incidence rate ratios for MACE among patients with a family history of CVD and psoriasis were 1.28 (95% CI, 1.12-1.46) for mild psoriasis and 1.62 (95% CI, 1.14-2.3) for severe psoriasis.
There was no increased risk of MACE for patients with mild or severe psoriasis and no family history of CVD.
“The findings suggest that a family history of CVD may be a primary determinant of the risk of CVD in patients with psoriasis,” the researchers wrote. “We found a significantly increased risk of first-time MACE in patients with psoriasis only when a family history of CVD was present. Future studies of CVD risk in psoriasis should include family history as a potential confounder, and increased focus on CVD in relatives may be appropriate in CVD risk assessment of patients with psoriasis.” – by Bruce Thiel
Disclosure: Egeberg reports no relevant financial disclosures. Please see the full study for a list of the other researchers’ relevant financial disclosures.
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