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High glycemic index, load values seen in patients with acne
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High glycemic index and glycemic load values and low adiponectin levels were associated with acne vulgaris, according to recent study results published in the Journal of the American Academy of Dermatology.
Aslı Aksu Çerman, MD, from the dermatology department at Şişli Hamidiye Etfal Training and Research Hospital in Istanbul, and colleagues measured the glycemic index values, glycemic load values, milk consumption, insulin, insulin-like growth factor-1, insulin-like growth factor binding protein-3, fasting glucose and adiponectin of 50 patients with acne vulgaris and 36 healthy controls. Patients in the acne group were subdivided groups based on their acne severity. There were no significant differences in gender, BMI or age between patients and controls.
The researchers found patients with acne had significantly higher glycemic index values (P = .022) and significantly higher glycemic load levels (P = .001) compared with control patients. Patients with acne vulgaris also had significantly lower serum adiponectin levels (P = .015) compared with patients in the control group, with serum adiponectin concentration having an inverse correlation with glycemic index (P = .049).
“We do not suggest that hypoadiponectinemia is a disease-specific finding, but that it is most likely associated with a high-glycemic-index/-load diet and might possibly serve as a cofactor that augments the inflammatory response in patients with acne vulgaris,” Çerman and colleagues wrote in their study. “Low-glycemic-index/-load diets may have therapeutic potential in the treatment of acne vulgaris, because of the beneficial metabolic and immunologic effects of these diets.” – by Jeff Craven
Disclosure: The researchers report no relevant financial disclosures.
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