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Baseline characteristics associated with erosion development in patients with psoriatic arthritis
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More than 12% of patients with psoriatic arthritis who were followed for at least 10 years did not develop erosions, and patients’ baseline characteristics were predictive of erosion development, according to study results.
Researchers conducted a retrospective analysis of patients from the University of Toronto psoriatic arthritis (PsA) cohort. There were 290 patients with at least 10 years’ follow-up included in the study. The modified Steinbrocker method was used to score radiographs.
Development of erosion with logistic regression models were predicted using baseline characteristics.
There were 36 erosion-free patients (12.4%) and 254 erosion-present patients (87.6%). Among erosion-present patients, the mean time to development of erosion during follow-up of 6.8 ± 6.1 years.
The patients in the erosion-free cohort were diagnosed at a younger age (22.5 ± 14.7 years) compared with the erosion-present patients (27.6 ± 12.1 years) at baseline.
“In both models, actively inflamed joints and clinically damaged joints were predictive of the development of erosion, whereas a longer duration of psoriasis at baseline decreased the odds of developing erosion,” the researchers wrote
There was a higher percentage of unemployment among the erosion-present patients compared with the erosion-free patients at baseline and during follow-up.
“Our results were persistent in both the regression analysis and the time-dependent analysis in predicting the development of erosions in peripheral joints over time,” the researchers concluded. “We found an association between baseline patient characteristics and the development of erosion over time. The relationship between the development of erosion and inflammatory activity suggests that patients with PsA should be treated aggressively for their active joint disease as early as possible.” – by Bruce Thiel
Disclosure: Touma reports support from Great-West Life, London Life and Canada Fellowship. The other researchers report no relevant financial disclosures.
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