Juvéderm Volbella reactions study tops January dermatology reads

Study results showing that patients who received injections of Juvéderm Volbella in the tear trough area or lips had a higher than expected incidence of late cutaneous reactions was among the most-read articles of January on Healio.com/Dermatology.

Other widely read articles included findings that anti-programmed cell death-1 therapy for melanoma was associated with eczema and vitiligo, and that Kybella treatment for submental fat reduction was safe and efficacious in a phase 3 trial.

Incidence of late reactions to Juvéderm Volbella higher than expected

Patients in Israel who received injections of Juvéderm Volbella in the tear trough area or lips had a higher than expected incidence of late cutaneous reactions, according to study results.

Researchers examined the medical records of 400 patients (360 women; average age, 49.6 years) who were treated with Juvéderm Volbella (hyaluronic acid) filler at four medical centers in Israel. Read more

Anti-PD-1 therapy for melanoma associated with eczema, vitiligo

Anti-programmed cell death-1 therapy for patients with metastatic melanoma was associated with cutaneous adverse events, including lichenoid reactions, eczema and vitiligo, according to recently published study results.

Researchers conducted a prospective and retrospective observational study with unresectable stage IIIC/IV metastatic melanoma treated with Keytruda (pembrolizumab, Merck) or Opdivo (nivolumab, Bristol-Myers Squibb) between May 1, 2012 and Feb. 1, 2015 at Westmead Hospital, Sydney, Australia. Read more

Early treatment may prevent skin necrosis related to nose augmentation with hyaluronic acid

Augmentation of the nose and nasolabial fold with hyaluronic acid may lead to impending nasal skin necrosis, according to study results.

Researchers in China reviewed medical records from between 2008 and 2014 to identify 20 patients (age range, 21 to 52 years; 90% women) who experienced skin necrosis associated with nose and or nasolabial fold augmentation with only hyaluronic acid fillers. Read more

Tumor depth tied to recurrence, metastasis of cutaneous SCC

Tumor depth was a significant risk factor for recurrence and metastasis of cutaneous squamous cell carcinoma, and a tumor diameter of more than 20 mm was a risk factor for disease-specific death, according to a results of a meta-analysis recently published in JAMA Dermatology.

Researchers at the Mayo Clinic, Rochester, Minnesota, conducted a literature search of Ovid Medline In-Process & Other Non-Indexed Citations, Medline, Embase, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews and Scopus from database inception through May 14, 2015. Read more

Kybella found to be safe, efficacious as submental fat treatment

Kybella treatment for submental fat reduction was safe and efficacious in clinician- and patient-assessed measures, according to recently published results from the REFINE-1 phase 3 trial.

Derek H. Jones

Derek H. Jones, MD, and colleagues studied 506 patients (83.2% women) at 35 centers throughout the United States and Canada between February 2012 and August 2013. Patients were dissatisfied with moderate or severe submental fat. Read more