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OnabotulinumtoxinA reduces cluster attack frequency

Cluster headache attacks were significantly reduced in frequency after administration of onabotulinumtoxinA towards the sphenopalatine ganglion, according to a study in Cephalalgia.

Researchers in the prospective, open-label, uncontrolled study injected 25 IU or 50 IU of onabotulinumtoxinA towards the sphenopalatine ganglion in 10 patients with intractable chronic cluster headache and evaluated the headache attack frequency at weeks 3 and 4.

There were 11 adverse events among seven patients, with one severe adverse event of posterior epistaxis.

The amount of cluster attack headaches was significantly reduced from 18 ± 12 per week at baseline to 11 ± 14 in weeks 3 and 4.

Furthermore, five out of 10 patients experienced at least a 50% reduction of attack frequency than at baseline.

Researchers discovered an average attack frequency reductions of 77%. – by Abigail Sutton

Disclosure: Bratback reported no relevant financial disclosures. For a complete list of relevant financial disclosures, please see the full study.