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Genetic, environmental factors contribute equally to rosacea in twins

Genetics and environment were equal contributors to rosacea development, according to recently published study results based on a survey of twins.

Researchers surveyed 550 identical and fraternal twins regarding risk factors implicated in rosacea at the annual Twins Day Festival in Twinsburg, Ohio, in August 2012 and August 2013. Each twin completed the survey, and analyses were conducted after each meeting. The National Rosacea Society (NRS) grading system was used to determine rosacea scores.

The mean rosacea score for the 233 identical twin pairs was 2.46; for the fraternal twins, the mean score was 0.75. Genetic contribution was demonstrated in a higher association between identical twins (r = 0.69) compared with fraternal twins (r = 0.46; P = .04). The genetic contribution was calculated to be 46% through use of the ACE conceptual model.

Age (r = 0.38; P < .001) and lifetime UV radiation exposure (r = 0.26; P < .001) also were associated with a higher NRS score. BMI (r = 0.21; P < .001), smoking (r = 0.1; P<.02), alcohol consumption (r = 0.11; P = .01), cardiovascular comorbidity (r = 0.17; P<.001) and skin cancer comorbidity (r = 0.19; P < .001) were other correlated variables.

“Using the criterion standard for genetic associations (ACE), we found that genetic and environmental factors each contributed to approximately half of the NRS score in our cohort,” the researchers reported.

“We have confirmed the importance of UV radiation as the single most important environmental variable, as well as uncovering other unexpected associations, such as BMI,” the researchers concluded. “These findings may help improve current management and expectations of individuals affected by rosacea.” – by Bruce Thiel

Disclosure: The researchers report no relevant financial disclosures.