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Botulinum toxin improves QoL and improves pain at rest in cutaneous leiomyoma

Botulinum toxin is associated with improvement in skin-related quality of life in individuals with cutaneous leiomyomas, according to researchers.

The researchers found that botulinum toxin may reduce pain at rest associated with cutaneous leiomyomas specifically by reducing pain intensity.

The randomized, double-blind, placebo-controlled study involved 18 patients with cutaneous leiomyomas who experienced pain at least once a week of at least a 4 on a pain scale of 0 to 10.

Participants were randomly assigned to intralesional botulinum toxin A or equivalent volumes of intralesional saline placebo.

Decreased pain was reported in the botulinum toxin group via visual analog scale scores before ice provocation, but this finding was not significant.

Researchers found a significant difference in skin-related quality of life by total Dermatology Life Quality Index and with the specific skin pain-related question on the Dermatology Life Quality Index.

Patients reported no serious adverse events related to the botulinum toxin use. – by Abigail Sutton

Disclosure: The researchers reported no relevant financial disclosures.