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Preoperative aprepitant with ondansetron reduces nausea, vomiting after facial plastic surgery

Rates of postoperative nausea and vomiting were greatly reduced in patients who took preoperative aprepitant with ondansetron within 1 hour before facial plastic surgery compared with ondansetron alone.

The retrospective study included 172 patients undergoing facial plastic surgery at a single center. Fifty-six patients received aprepitant with ondansetron as prophylaxis for postoperative nausea and vomiting.

The postoperative nausea and vomiting rate reduced from 15.5% with ondansetron alone to 1.8% with the addition of aprepitant.

Surgery lasting longer than 90 minutes, female sex and type of facial plastic surgery were independent risk factors for postoperative nausea and vomiting, according to researchers.

Of the 19 patients who experienced postoperative nausea and vomiting, 17 were women and 17 had surgery lasting longer than 90 minutes.

Of those that did not receive preoperative aprepitant, 17% of women and 9.1% of males experienced postoperative nausea and vomiting.-by Abigail Sutton

Disclosures: The researchers reported no relevant financial disclosures.