Study: Juvéderm demonstrates greater improvement than Belotero in treating perioral lines
SAN FRANCISCO — Juvéderm showed a higher response rate and greater improvement in the treatment of moderate-to-severe perioral lines compared with Belotero, according to research presented at a late-breaking research session during the American Academy of Dermatology Annual Meeting.
Kimberly Butterwick, MD, and colleagues conducted a 6-month, double-blind, controlled multicenter study comparing Juvéderm Ultra (24 mg/mL hyaluronic acid, 0.3% lidocaine; HYC-24L, Allergan) with Belotero Balance (22.5 mg/ml hyaluronic acid; CPM-22.5, Merz Aesthetics) as treatment for 136 adults who had moderate-to-severe perioral lines. Patients’ mean age was 58 years. One hundred thirty-one patients completed the study.
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Butterwick
The products were not diluted and came straight from the bottle, Butterwick said. Pain was measured before and after treatment, and bruising and Tyndall effect were measured after treatment.
A comparison of rater-assessed responder rates by a validated four-point Perioral Lines Severity Scale at 6 months was used as the study’s primary endpoint. Patients with a one-point improvement were defined as responders. The total volume injected was 1.18 cc for patients who received HYC-24L and 1.32 cc for patients who received CPM-22.5.
Eighty-seven percent of patients in the HYC-24L treatment arm reached endpoint compared with 72% of patients in the CPM-22.5 cohort. A significantly greater improvement in perioral lines was reported by patients treated with HYC-24L compared with those treated with CPM-22.5 at all times points, with the greatest difference between the two cohorts reported at 6 months (P < .001), according to the researchers. There were no unexpected adverse events. One Tyndall effect was reported in the CPM-22.5 cohort.
“Both products had a similar look, a natural feel and ease of injection, but HYC-24L provided more effective correction with less pain than CPM-22.5,” Butterwick said. “HYC’s greater persistence of effectiveness at month 6 suggests that it may exhibit a longer duration of benefit than CPM.” – by Bruce Thiel
Reference:
Butterwick K. Paper #F056. Late‐breaking Research: Surgical & Cosmetic. Presented at: American Academy of Dermatology Annual Meeting. March 20-24, 2015, San Francisco.
Disclosures: Butterwick and the other study investigators received research grants from Allergan.