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Grafted fat shows variable response following transplantation

In a literature review to identify the histology of grafted fat after transplantation, researchers found variable responses with significant disagreements in previous studies.

Using the Medline and Cochrane Central Register of Controlled Trials databases to review literature up through December 2013, the researchers identified 66 articles for inclusion, eight of which were human studies and seven of which reported on the histology of aspirated fat. The studies incorporated a wide variety of methods for fat harvesting and transfer, as well as a number of different sources from which fat was obtained. Additionally, the time to harvest of grafted fat ranged from 0 to 65 months, according to the researchers.

Although many of the studies reported the presence of viable adipocytes, the researchers observed an extensive amount of fibrosis and inflammatory infiltration, as well, depending on the period of examination.

The researchers concluded that although the neovascularization and preservation of adipocyte architecture appear to be possible, other fat grafts are replaced completely by necrotic "ghost" cells and fibrotic ingrowth.

They also concluded that although adipose survival more than likely contributes to volume maintenance, inflammation and fibrosis may also play an integral part in the clinical effects achieved from fat grafting. - by Abigail Sutton

Disclosure: Harrison reported no financial disclosures. Please see the full study for a list of all other authors' relevant financial disclosures.