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FLG mutations may affect anatomical dermatitis patterns in patients with AD history

Lifetime prevalence of dermatitis on the hands and feet were affected by filaggrin null mutations in patients with a history of atopic dermatitis, according to recently published study results.

Researchers in Denmark studied data from a population-based cohort of 2,143 participants between the ages of 18 and 72 years from the general population. Follow-up was 5 years. Questionnaires were completed to obtain information on dermatitis on hands, feet, face, axillae, abdomen, chest or back. Common flilaggrin (FLG) null mutations, including R501X, 2282del4 and R2447X, were determined by genotyping, and United Kingdom Working Party’s diagnostic criteria were used to define a history of atopic dermatitis (AD).

The researchers found there was an association between FGL genotype and frequency of foot dermatitis (P = .014) within the general population. FLG mutations increased foot dermatitis prevalence (OR = 10.41; 95% CI, 5.27-20.6) and persistent hand dermatitis (OR = 17.57; 95% CI, 8.6-35.89) only in participants with AD, according to stratification of FLG genotype and AD.

Lifetime prevalence of dermatitis was not affected by FLG mutations in participants who had no history of AD, which suggested that the atopic phenotype was a significant factor, according to the researchers.

The researchers concluded that knowledge of previous foot dermatitis in patients with AD could aid in determining potential FLG mutation carriers. – by Bruce Thiel

Disclosure: The researchers report no relevant financial disclosures.