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Hyaluronic acid-based filler improves clinical signs of facial aging

According to recently published study data, a hyaluronic acid-based dermo-cosmetic treatment improved sagging of the face and cheekbones contours, lip volume, and decreased wrinkle depth and volume in a sample of female patients.

The placebo-controlled, double-blind, randomized clinical trial included 40 women between the ages of 25 and 55 with mild-to-moderate clinical signs of skin aging. Researchers assessed the effects of Fillerina (hyaluronic acid 1 K Da, hydrolyzed sodium hyaluronate 5 K Da, hydrolyzed hyaluronic acid 50 K Da, sodium hyaluronate 200 K Da, sodium hyaluronate 2.000 K Da, sodium hyaluronate crosspolymer; Labo Cosprophar) at 3 hours after a single application and again at 7, 14 and 30 days after continuous daily use.

The researchers found lip volume increased at all points of follow-up. Additionally, by days 7, 14 and 30, skin sagging of the face and cheekbones contours was reduced, cheekbone volume was increased, and wrinkle volume and depth had decreased, according to the researchers.

Treatment efficacy was found to be stronger in lessening the cheekbones skin sagging compared with face contour skin sagging, which the researchers reported may have been due to the severity of skin sagging and the extent of the two skin sites.

The researchers concluded that the topical application of low-molecular-weight hyaluronic acid successfully improved skin moisturization and elasticity associated with a significant reduction of wrinkle depth. – by Abigail Sutton

Disclosure: The authors have no relevant financial disclosures.