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Psoriasis may be an independent risk factor for subclinical atherosclerosis
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Both psoriasis and mean intima-media wall thickness of the common carotid artery were positively correlated with certain biomarkers, indicating that psoriasis may be a potential independent risk factor for subclinical atherosclerosis, according to study data.
Researchers determined the mean intima-media wall thickness of the common carotid artery and leptin, resistin, triglyceride and total cholesterol levels in serum for 60 patients with psoriasis and 60 healthy, age-matched controls.
Patients with psoriasis were found to have significantly higher serum leptin, resistin, triglyceride and total cholesterol levels, according to the researchers. The mean intima-media wall thickness of the common carotid artery of patients with psoriasis was also significantly greater than that of the healthy controls.
The researchers found positive correlations between serum resistin levels and age, BMI and serum triglyceride concentration in both groups. The serum resistin concentration was also directly correlated with the mean intima-media wall thickness of the common carotid artery in the psoriasis group, according to the researchers.
Twelve patients with psoriasis and one healthy control were found to have subclinical atherosclerosis.
The researchers concluded that serum leptin and resistin levels can be used as biomarkers for subclinical atherosclerosis in patients with psoriasis.
Disclosure: The authors have no relevant financial disclosures.
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