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Tumor site in patients with ENKTL affects survival outcomes
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In patients with cutaneous extranodal natural killer/T-cell lymphoma, researchers found that survival outcomes and prognostic factors were influenced by primary tumor location.
Forty-five patients with cutaneous extranodal natural killer/T-cell lymphoma (ENKTL) were included in the study. Patients were classified into two groups: those with primary cutaneous ENKTL (group A; n = 28) and those with nasal ENKTL with cutaneous involvement (group B; n = 17). The researchers defined primary cutaneous ENKTL as a skin-only disease at initial staging, whereas nasal ENKTL with cutaneous involvement was defined as a primary tumor in the upper aerodigestive tract that spread to the skin.
Patients in group B had significantly less favorable outcomes compared with those in group A, according to the researchers. Group A’s overall survival rate was 57% vs. 21% in group B (P = .028). Mean progression-free survival was also significantly better in group A than in group B, at 16 months vs. 8 months (P = .003).
Patients who had nasal lesions secondary to primary cutaneous ENKTL had worse overall survival rates compared with those who did not (25 months vs. 42 months; P = .011), according to the researchers.
Disclosures: The authors have no relevant financial disclosures.
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