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Cesarean delivery showed link with gut microbiota, atopic dermatitis
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SAN DIEGO — Cesarean delivery and prenatal antiobiotic exposure had a possible effect on gut microbiota, which in turn influenced the risk for infant atopic dermatitis, according to late-breaking data presented at the 2014 American Academy of Allergy, Asthma and Immunology annual meeting.
Researchers evaluated 412 infants in a prospective birth cohort study. Interleukin (IL) 13 (rs20541) and CD14 (rs2569190) genotype analysis was conducted on cord blood DNA. Eleven infants at age 6 months had fecal samples obtained, with 16s ribosomal RNA bacterial gene sequencing conducted.
Atopic dermatitis (AD) had a positive and significant association with the combination of cesarean delivery and prenatal exposure to antibiotics (adjusted OR=5.7; 95% CI, 1.19-27.3). Parental history of allergic diseases or risk-associated IL-13 and CD14 genotypes significantly modified the association between cesarean delivery and AD.
There was lower total microbiota diversity in stool samples in infants who were exposed prenatally to antibiotics and born by cesarean delivery compared with a control group. AD risk rose with increasing number of risk factors (trend P<.05).
“These relationships may be shaped by the genetic susceptibility alleles,” the researchers concluded.
Lee SY. Abstract L9. Presented at: AAAAI; Feb. 28-March 4, 2014; San Diego.
Disclosure:So Yeon Lee, MD, PhD, reported no relevant financial disclosures.