June 03, 2013
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Complications from injectable soft-tissue fillers rare

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Complications were rare following injectable soft-tissue filler treatments, according to results of a 5-year retrospective study.

Researchers conducted a medical record review of patients undergoing treatment with injectable soft-tissue fillers in a private practice between Jan. 1, 2007, and Dec. 31, 2011, who were identified as having complications related to treatment.

There were 2,089 injectable treatments performed (1,047 with hyaluronic acid, 811 with poly-L-lactic acid and 231 with calcium hydroxylapatite). Among 14 complications observed, nodule or granuloma formation (n=7) occurred most frequently. The highest complication rate involved calcium hydroxylapatite (2.6%).

“Despite a policy to see all patients treated with injectable soft-tissue fillers for scheduled follow-up visits to document all complications in the quality assurance reports, it is possible that we were unable to capture every adverse event that occurred during the study period,” the investigators said, writing that the study’s design was a “significant shortcoming.”

“Injectables are not without risk,” the researchers concluded. “It is important to be aware of the spectrum of potential adverse sequelae and to be comfortable with their proper management.”