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Platelet-rich fibrin matrix injections linked to encouraging cellular changes

Injection of autologous platelet-rich fibrin matrix was associated with a number of cellular effects, including activated fibroblasts and new collagen deposition, according to recent results.

Researchers aimed to evaluate the histological changes induced in the skin of four healthy adult volunteers by injection of autologous platelet-rich fibrin matrix (PRFM).

The injection was prepared from 9 mL of autologous blood using a proprietary system (Selphyl, Aesthetic Factors). Participants were injected in the deep dermis and immediate subdermis of the upper arms.

The researchers took full thickness skin biopsy specimens from the treated areas during a 10-week period. Histological evaluation was conducted on the specimens and supported the clinical observation of soft-tissue augmentation, according to the results. Activated fibroblasts and new collagen deposition were observed as early as 7 days after treatment. This continued through the study duration.

Nineteen days after treatment, development of new blood vessels was observed. Intradermal collections of adipocytes and stimulation of subdermal adipocytes also were observed at the 19-day mark. The fibroblastic response became less pronounced through the study duration, but the other observations became more pronounced.

There were no abnormal mitotic figures observed at any point. At the earliest time points, a chronic inflammatory response was reported, but it was very mild.

“Coupled with prior in vitro and in vivo studies, we now have a much clearer picture of the cellular effects of PRFM and its potential uses in facial plastic surgery,” the researchers wrote. “Further work is planned to more clearly elucidate the potential role of PRFM in aesthetic and reconstructive surgery.”