European Society of Cardiology
DANISH: Prophylactic ICD implantation not superior to usual care in some patients with systolic HF
In patients with symptomatic systolic HF not due to CAD, prophylactic implantation of an implantable cardioverter defibrillator did not improve outcomes compared with the usual care, according to the results of the DANISH study.
ESC position paper addresses cardiotoxicity of cancer therapies
The European Society of Cardiology released a position paper outlining which cancer therapies may put patients at risk for adverse CV events, and measures that can be taken to reduce risk.
CLARIFY: Low BP linked with adverse CV outcomes in high-risk patients
In patients with stable CAD, BP below 120 mm Hg systolic or 70 mm Hg diastolic was associated with elevated risk for CV death, MI and stroke, according to findings from the CLARIFY registry.
BASKET-SAVAGE: DES superior to BMS for revascularization of saphenous vein grafts
In patients requiring revascularization of saphenous vein grafts, drug-eluting stents were more effective than bare-metal stents, according to the results of the BASKET-SAVAGE trial.
NORSTENT: DES not superior to BMS for death, MI in patients undergoing PCI
In the largest randomized stent trial conducted to date, second-generation drug-eluting stents and contemporary bare-metal stents were associated with similar rates of death and MI, according to findings presented at the European Society of Cardiology Congress.
PRAGUE-18: Prasugrel, ticagrelor confer similar outcomes in patients with STEMI undergoing PCI
In the first randomized, head-to-head comparison of prasugrel and ticagrelor, the drugs were associated with similar short-term outcomes in patients with STEMI who received them before PCI.
DOCTORS: OCT-guided PCI associated with better outcomes than standard PCI
PCI guided by optical coherence tomography was linked with better clinical outcomes vs. standard angiography-guided PCI, according to results of the DOCTORS study presented at the European Society of Cardiology Congress.
ANNEXA-4: Reversal agent effective in patients with acute major bleeding after Factor Xa inhibitor use
Andexanet alfa, a novel reversal agent, was effective at stopping acute major bleeding in patients taking Factor Xa inhibitors, according to results from the ANNEXA-4 study.
ENSURE-AF: Edoxaban noninferior to standard anticoagulation before cardioversion in patients with AF
In patients with atrial fibrillation undergoing cardioversion, edoxaban conferred similar outcomes to the standard care of warfarin plus enoxaparin, according to findings from the ENSURE-AF study presented at the European Society of Cardiology Congress.
PACIFIC: PET superior to other modalities for diagnosis of myocardial ischemia
In a head-to-head comparison of noninvasive imaging modalities, PET was more accurate than coronary CT angiography or single-photon emission CT at diagnosing myocardial ischemia.