European Society of Cardiology
Six highlights from ESC Congress 2014
Digoxin raised risk for death in ROCKET AF subanalysis
ENGAGE AF-TIMI 48: Edoxaban dose reduction improved clinical outcomes
BARCELONA, Spain — In a subgroup analysis of the ENGAGE AF-TIMI 48 trial, patients with clinical factors known to increase risk for bleeding due to higher drug exposure who were administered a reduced edoxaban dose had decreased drug concentrations and anti-factor Xa activity, rates of stroke or systemic embolic events consistent with those who did not receive a dose reduction and greater relative reductions in bleeding compared with warfarin.
ENGAGE AF-TIMI 48: Edoxaban dose reduction improved clinical outcomes
BARCELONA, Spain — In a subgroup analysis of the ENGAGE AF-TIMI 48 trial, patients with clinical factors known to increase risk for bleeding due to higher drug exposure who were administered a reduced edoxaban dose had decreased drug concentrations and anti-factor Xa activity, rates of stroke or systemic embolic events consistent with those who did not receive a dose reduction and greater relative reductions in bleeding compared with warfarin.