Genetics/Genomics News

Healthy carriers of a genetic mutation for arrhythmogenic right ventricular dysplasia/cardiomyopathy who participate in endurance sports or frequent exercise are more likely to develop symptoms of the disease, ventricular arrhythmias and HF, according to new data.

People with a certain gene that has been naturally “switched off” appear to be at increased CV risk, researchers reported at an American Heart Association Emerging Science Series webinar.

People with a certain gene that has been naturally “switched off” appear to be at increased CV risk, researchers reported at an American Heart Association Emerging Science Series webinar.

Researchers have identified a common genetic variation that can influence the therapeutic dose of warfarin in African Americans. The discovery, reported online in The Lancet, demonstrates that those of African ancestry who carry the rs12777823 variant may require a lower dose of warfarin as compared with those who do not carry the single nucleotide polymorphism, according to a press release.

About 10% of congenital heart defects are caused by spontaneous de novo mutations, according to findings from a new study.

In a molecular genetic evaluation of 91 cases of intrauterine fetal death, mutations associated with susceptibility to long QT syndrome were discovered in a small number of cases. This finding demonstrates preliminary evidence that may provide insights into the mechanism of some intrauterine fetal deaths, researchers reported in JAMA.

Beginning on Saturday, March 9, the Cardiology Today and Healio.com/Cardiology team will present live coverage from the American College of Cardiology’s 62nd Annual Scientific Sessions and TCT@ACC-i2.

New data published in The Lancet suggest that elevated LDL in a significant number of patients diagnosed with familial hypercholesterolemia may have polygenic rather than monogenic causes.

Researchers have discovered a gene associated with a form of cholesterol that increases the risk for developing aortic stenosis by more than half.

The following are the Top 10 stories of 2012 in the field of cardiology. These developments and issues were selected and deemed important by members of the Cardiology Today Editorial Board. The editors of Cardiology Today value your opinion. Let us know what you think of the Top 10 list.