Genetics/Genomics News

A minor allele of vascular endothelial growth factor A was associated with improved survival after surgery for congenital heart disease in infants, and the mechanism appears to be preservation of ventricular function.

Researchers have identified genetic mutations that truncate titin, a muscle filament, and cause dilated cardiomyopathy.

New research demonstrates that the effects of dalcetrapib on atherosclerotic outcomes may be affected by polymorphisms on the ADCY9 gene.

Mutations that disrupt the function of the protein encoded by the NPC1L1 gene are associated with reduced plasma LDL levels and a lower risk for CHD, according to data published in The New England Journal of Medicine.

New research provides evidence of a causal association between LDL and aortic valve disease. Researchers found that genetic predisposition to elevated LDL was associated with the presence of aortic valve calcium and the incidence of aortic stenosis.

A genetic risk score derived from 12 genetic variants associated with increased risk for atrial fibrillation improved the identification of individuals with increased risk for AF and ischemic stroke, according to study data.

Researchers have created a minimally invasive gene transplant procedure that turns unspecialized heart cells into “biological pacemaker” cells.

A new guideline from the European Atherosclerosis Society recommends quick diagnosis and referral to specialist centers for patients with homozygous familial hypercholesterolemia.

New genetic research has identified a causal link between increased plasma concentrations of 25-hydroxyvitamin D and reduced risk for hypertension.

Several mutations of cytochrome P450 isoenzymes are associated with increased risk for mortality in patients taking clopidogrel after acute MI; however, the specific mutations and mechanisms of action vary by race, according to new study findings.